Recommended Therapeutic Range for Oral Anticoagulation Therapy
|
Indication |
Target INR |
Range |
|
Prophylaxis of venous thrombosis (high-risk surgery) |
2.5 |
2.0-3.0 |
|
Treatment of venous thrombosis |
2.5 |
2.0-3.0 |
|
Treatment of pulmonary embolism |
2.5 |
2.0-3.0 |
|
Prevention of systemic embolism Tissue heart valves Acute MI (to prevent systemic embolism)* Valvular (rheumatic) heart disease Atrial Fibrillation |
2.5 2.5 2.5 2.5 2.5 |
2.0-3.0 2.0-3.0 2.0-3.0 2.0-3.0 2.0-3.0 |
|
Mechanical prosthetic valves (high-risk) |
3.0 |
2.5-3.5 |
|
Bileaflet mechanical valve in aortic positions |
2.5 |
2.0-3.0 |
*If oral anticoagulant therapy is elected to prevent recurrent myocardial infarction an INR of 2.5-3.5 is recommended. This is consistent with the Food and Drug Administration recommendations.